The innovative preparation contains a complex of substances that form a chain of synergic reactions, thanks to which they increase intellectual capacity to the highest extent possible. Brain Fuel™ v2 contains:
Caffeine – alkaloid with well- documented energising and fatigue-reducing properties. It stimulates the release of dopamine, adrenaline and noradrenaline from presynaptic membranes, which leads to the characteristic stimulant, concentration-improving and sense-sharpening effects. Caffeine is also a competitive inhibitor of the enzymes phosphodiesterases, thanks to which it can increase cAMP levels inside cells.
The reduction of fatigue is possible thanks to its interaction with the adenosine system. After binding with receptors specific for it, adenosine inhibits the activity of the nervous system and causes tiredness. It is possible to reduce fatigue by blocking the access of adenosine to receptors, which is one of the properties of caffeine.
N-Acetyl L-tyrosine – a highly assimilable form of tyrosine, valued for its ability to enhance concentration and stimulate mildly. Tyrosine converts to L-DOPA and then to dopamine, thanks to which it can supplement the reserves of neurotransmitters depleted by caffeine. It can potentially reduce a sudden energy drop after caffeine stops working and stimulate its activity to some extent.
Sunifiram – a paracetamol derivative, an ampakine. The name stems from the ability of the group to activate AMPA receptors, although indirectly. The base of the agent’s activity is its influence on the activation of the place of glycine binding with the NMDA receptor. That results in more intensive phosphorylation of some proteins inside neurons, mainly CAMKII and PKCα. Subsequently, AMPA receptors are stimulated. The influence on the glutamatergic system leads to an increase in brain activity, as it is a typical stimulant neurotransmitter. By reacting with the system, sunifiram can stimulate the long-term potentiation of synapses, which is a basic mechanism in terms of forming memory. It means modifications in the synapse structure, which results in more efficient signal transmission between neurons and, as a result, better information assimilation and its recalling.
Another advantage of sunifiram and a mechanism that is even more beneficial for effective learning is its ability to increase acetylcholine release to synapses in the area of the prefrontal cortex. The part of the brain is responsible for controlling decision making so that they are logical and comply with standards, the ability to plan and organise, and generally for working memory.
Coluracetam – a chemical compound belonging to racetams, that is a group of nootropic agents. The main benefit obtained from it is its ability to prevent the bottleneck in the process of acetylcholine synthesis, that is the efficacy of choline uptake to neurons. The process is referred to as high-affinity choline uptake (HACU). Its stimulation enables more efficient acetylcholine production, which is then released in larger amounts, especially in the hippocampus, which is responsible for long-term memory. The influence on memory formation is even greater because of its agonist effect on AMPA receptors.
A special property of coluracetam is its potential ability to improve the mood and perception of the world. Users have often reported an improvement in visual and auditory perception. Clinical trials, on the other hand, have demonstrated the antidepressant and anxiolytic properties of coluracetam.
To sum up, the combination of those components works in synergy to affect energy levels, the mood, and the efficacy of cognitive functions. Their blend gives much stronger effects than their separate use, and the interactions between them form a unique whole, pushing the brain to show its highest potential.