Apollo’s Hegemony Berberine is a dietary supplement containing 300 mg of berberine hydrochloride in each capsule. It demonstrates a strong effect regulating the level of sugar in blood, optimizes insulin-leptin environment, intensifies the processes of glycolysis and lipolysis and balances lipid profile.

Berberine is an alkaloid which has gained popularity thanks to traditional Chinese medicine, where it is appreciated for its comprehensive activity. Its effect is based on stimulating AMPK kinase and inhibition of convertase PCSK9 and phosphatase PTP1B. Thanks to affecting these three, powerful metabolism regulators, berberine constitutes a universal supplement, the effect of which not only facilitates fatty tissue reduction, but also positively influences health, especially cardiovascular system. 

Body mass control
Kinase activated by AMP, i.e. AMPK is an intracellular mechanism controlling the state of cell nourishment and regulating it. The stimulator of its activity is the increase of the concentration of adenosine monophosphate, which is the last product of ATP breakdown, i.e. the main source of energy for all cells. In order to rebuild the stores of adenosine triphosphate, AMPK stimulates the work of all energy processes of the organism, which leads to the increase of lipolysis and glycolysis and also the increase of the uptake of free fatty acids and glucose from blood. Thanks to this, the metabolism of the provided nutrients becomes more efficient and burning spare fatty tissues is more intensive.

Regulating sugar level in blood
The activity of berberine towards carbohydrates is reflected not only in facilitated burning of fat, but it also has a positive effect on the organism’s health. AMPK activation increases insulin secretion and sensitivity of insulin receptors GLUT-4, which in turn is reflected in lower sugar level in blood and its increased amount in skeletal muscles. It allows to perform longer and more intensive effort and it also secures the organism from the development of insulin-resistance appearing in extreme cases as the development of diabetes type II.

Cardiovascular system health
Thanks to regulating the concentration of sugar in peripheral blood, berberine is also a great means protecting the state of blood vessels. It prevents protein glycation (which may be clearly noticed in the drop of glycosylated hemoglobin in blood), which is the main cause of the creation of micro- and macroangiopathy with atherosclerosis at the front-line.

As for the health of blond vessels, berberine also acts by inhibiting convertase PCSK9. Inhibiting the effect of PCSK9 in the organism provides the effect in the form of lower total cholesterol in the organism and normalization of the ratio of HDL to LDL.

Mood elevation
Thanks to the optimization of energy processes in all cells of the organism, berberine improves well-being, decreases anxiety and has antidepressant effect. Its activity in this matter is so strong that it is more and more often recommended as the supplementation in antidepressant therapies.

Appetite control
Phosphatase PTP1B is commonly considered as an obesity factor, deregulating proper mechanisms of insulin and leptin activity in the organism. It contributes to metabolic disorders giving the symptoms of increased fatty tissue storage and appetite stimulation regardless of the size of food intake. Berberine exhibits the effect inhibiting the activity of PTB1B, which is yet another mechanism facilitating regulating body mass.

Summing up, Berberine is a complex supplementation of the plan oriented to reducing fatty tissue. In a safe and non-invasive way it stimulates the processes leading to the increase of the pace of weight loss, simultaneously improving the condition of the organism, with the special emphasis on the health of blood vessels.