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  • Weight control
  • Thermogenic activity
  • Appetite reduction 
  • Metabolism boost
  • Ephedra-free fat burner
  • Ergogenic potential
  • Energy boost
  • Increased mental focus
Apollo's Hegemony Synephrine HCL is a dietary supplement containing 20 mg of synephrine HCl per vegetarian capsule. Synephrine (p-synephrine) is a naturally occurring protoalkaloid and the main active substance in bitter orange (Citrus aurantium), widely used for weight management, appetite reduction, energy and focus.

Synephrine was at first synthetically produced as a sympathomimetic drug; however, it was later found in and isolated from the leaves and fruits of several species of the Citrus genus, especially bitter orange. Its peel contains p-synephrine (para-synephrine), which is different from m¬-synephrine, also known as phenylephrine.

Synephrine stimulates alpha-adrenergic and, to some extent, beta-adrenergic receptors. It is viewed as a non-selective beta-3 agonist, which can activate lipolysis and, as a result, affect body weight and adipose tissue levels.

Research indicates that p-synephrine increases lipolysis, fat oxidation, oxygen consumption, energy expenditure and carbohydrate metabolism as well as reduces appetite. Apart from that, it boosts physical energy levels. Studies show that, contrary to popular belief, p-synephrine is active only as a metabolism booster without exerting any stimulant effect on the cardiovascular system.

Chemically speaking, the structure of synephrine is similar to ephedrine, because of which the former is considered a natural substitute of the latter. However, synephrine is not a doping substance and, as mentioned above, has no significant effects on the cardiovascular system, which are often associated with ephedrine and catecholamines, such as increased heart rate and blood pressure.

To sum up, Apollo's Hegemony Synephrine contains a natural substance that efficiently supports weight loss and provides a mild energy boost. The product is recommended for athletes and individuals aiming at weight loss.

The product can be used as a pre-workout dietary supplement. Preferably, take 30-60 minutes before workout. 

P-synephrine displays synergy with caffeine and its effects are stronger in caffeine-naïve users.

For fat loss purposes, synephrine can be combined with yohimbine.

Based on detailed human, animal and in vitro safety studies, bitter orange extracts standardized to p-synephrine have received self-affirmed GRAS (Generally Recognized as Safe) status. 

If you are taking any medication, consult your doctor or pharmacist before taking the supplement. 
This product has not been tested for the presence of substances banned by WADA.
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